![]() Male Sprague-Dawley rats weighing 250-300 g were anesthetized by intramuscular injection of zoletil (15 mg/kg, Virbac Laboratories, Carros, France). Preparation of aortic rings for tension measurement was performed as previously described. We tested the hypothesis that the extent of lipid emulsion-mediated reversal of vasodilation induced by a toxic dose of local anesthetic may be dependent upon the kind of triglyceride (long- or medium-chain). ![]() Therefore, the goal of this in vitro study was to investigate the ability of Lipofundin® MCT/LCT and Intralipid® to reverse vasodilation induced by toxic doses of local anesthetics (bupivacaine, ropivacaine, lidocaine, and mepivacaine) in the isolated rat aorta. However, studies investigating the ability of these two lipid emulsions (Lipofundin® MCT/LCT and Intralipid®) to extract local anesthetics and promote recovery from cardiac arrest induced by a toxic dose of bupivacaine have reported inconsistent results. Vaconstriction potency induced by local anesthetics is mainly determined by lipid solubility, among the physicochemical properties of local anesthetics. Intralipid®, which consists of 100% long-chain triglycerides, is commonly used to treat local anesthetic systemic toxicity, and Lipofundin® MCT/LCT, which consists of 50% long-chain triglycerides and 50% medium-chain triglycerides, is sometimes used to treat local anesthetic systemic toxicity. SMOFlipid® emulsion has been shown to reverse vasodilation induced by a toxic dose of levobupivacaine in the isolated rat aorta. Thus local anesthetics have a dose-dependent vascular effect, inducing vasoconstriction at low doses and inducing vasodilation (release of vasoconstriction) at high doses. ![]() Toxic doses of local anesthetics that belong to the n-alkyl-substituted pipecholyl xylidine family inhibit the voltage-operated calcium channel-mediated contraction induced by low doses of local anesthetic. Intravenous lipid emulsions such as Intralipid® and Lipofundin® MCT/LCT have been used to treat local anesthetic systemic toxicity.
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